Implementation of a central organization and allocation organizations
(1) Drafting of a strategy/Execution evaluation
The research steering committee is organized by specialists in three fields of the life sciences, information technology, and life sciences databases. At meetings of this committee, a strategy for database infrastructure that suits the trends in each field is developed. In addition, information concerning the trends in the three fields is collected and analyzed daily, and the team that supports the drafting of the strategy and the execution evaluation is coordinated.
(2) Development of integrated databases
A human integrated database and a model organism integrated database are being constructed and operated, with the aim of improving access to information related to the life sciences and bioindustry, improving the usability, and dramatically improving the efficiency and quality of research and development. To achieve this, the necessary technology for constructing integrated databases, for the standardization of databases and for information processing (for example, knowledge acquisition from documents), is being developed.
(3) Support for integrated databases
Individual open databases and analysis tools are being investigated, and a portal site is being constructed. To operate this, a system that summarizes the opinions of both specialists and users is being developed, and the opinions will be fed back. The distribution of information related to research is being promoted. Once a project database has been accepted, it is converted into a form that can operate alongside the others, and opened to the public. Training and education are carried out within the hierarchy in cooperation with the experienced organizations.
An integrated database that focuses on molecular information is being constructed at the Kyoto University Bioinformatics Center. A search engine for the integrated database in Japanese will be offered after 6 months. Innovative web technology and a system that has been manually constructed in the Kyoto Encyclopedia of Genes and Genomes (KEGG) are being united, and an intellectual information base at the highest level available in the life sciences field worldwide will be established by 2010.
(Tokyo Medical and Dental University)
A method to improve and integrate clinical and disease databases in the life sciences field is being developed, and an integrated cross-sectional medical database with a hierarchy from the molecular to the individual level is being constructed. Cancer diseases and neurological disorders are being targeted and demonstrated.
(The University of Tokyo)
Genome-wide single-nucleotide polymorphisms (SNPs) are being typed, and the genes that cause or are related to diseases are being re-sequenced. The data are being compiled into a database by analyzing the relationships between clinical information and genetic information. Using this database, we aim to promote the identification of hereditary determinants in diseases, gene diagnosis, and research into the molecular epidemiology of diseases, as well as to advance achievements in individual medical treatment.